About
Trent Orfanos, MD serves as Director of Integrative and Functional Cardiology at Case Integrative Health. He earned his Bachelor of Arts in Biological Sciences and his Doctorate of Medicine from Indiana University. Dr. Orfanos completed his residency in Internal Medicine at St. Vincent Hospital in Indianapolis, then pursued a cardiology fellowship under Edward Steinmetz, MD.
He holds five board certifications: Internal Medicine, Cardiology, Integrative Medicine, Functional Medicine, and Antiaging Medicine. Dr. Orfanos is also a Fellow of the American College of Cardiology and a Fellow of the American Academy of Anti-Aging Medicine. He practiced adult invasive, nuclear, noninvasive, and interventional cardiology from 1982 to 2019. Beginning in 2010, he incorporated preventive cardiology from a functional medicine perspective alongside his interventional practice. He watched patients flourish with functional medicine interventions after plateauing under conventional care alone. That outcome drew him fully into integrative cardiology. His clinical interests include longevity, healthy aging, preventive cardiology, stress management, and sleep hygiene.
Education & Training
Undergraduate
Indiana University, BA in Biological Sciences
Medical School
Indiana University, MD
Residency
Internal Medicine, St. Vincent Hospital, Indianapolis
Fellowship
Cardiology fellowship under Edward Steinmetz, MD
Certifications
Conditions Treated
Who is Dr. Orfanos right for?
Dr. Orfanos is a strong fit for adults with cardiovascular concerns who want more than a conventional workup. Patients managing heart disease, metabolic dysfunction, or chronic stress benefit from his integrative approach. He works well with those focused on healthy aging, longevity, and sleep optimization. Patients who have plateaued on standard cardiac care and want a functional medicine perspective will find his dual background particularly valuable.
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Frequently Asked Questions
Dr. Orfanos specializes in integrative and functional cardiology, internal medicine, and preventive medicine. He holds board certifications in all five areas: Internal Medicine, Cardiology, Integrative Medicine, Functional Medicine, and Antiaging Medicine. He focuses on identifying root causes of cardiovascular and metabolic conditions rather than managing symptoms alone.
Dr. Orfanos practiced adult invasive, nuclear, noninvasive, and interventional cardiology from 1982 to 2019. That spans nearly four decades of clinical cardiology experience. Starting in 2010, he incorporated functional and preventive cardiology alongside his interventional work.
Yes. Dr. Orfanos holds five board certifications: Internal Medicine, Cardiology, Integrative Medicine, Functional Medicine, and Antiaging Medicine. He also holds fellowship status in both the American College of Cardiology and the American Academy of Anti-Aging Medicine.
Dr. Orfanos earned his BA in Biological Sciences and his MD from Indiana University. He completed his Internal Medicine residency at St. Vincent Hospital in Indianapolis, then trained in cardiology under Edward Steinmetz, MD.
Dr. Orfanos focuses on longevity, healthy aging, preventive cardiology, stress management, and sleep hygiene. He approaches these topics through a functional medicine framework, looking for root causes behind cardiovascular and metabolic decline.
Dr. Orfanos typically sees adults with cardiovascular concerns, metabolic dysfunction, or chronic health challenges that have not fully responded to conventional treatment. He also works with patients focused on proactive aging and long-term wellness.
Dr. Orfanos began incorporating functional medicine into his cardiology practice in 2010. He observed patients improve significantly with functional medicine interventions after reaching a plateau under conventional care alone. That clinical experience drew him fully into integrative cardiology.
Doctor profile last updated March 21, 2026