About
Sean D. O'Connor, MD completed his undergraduate training in biology at Hope College in Holland, Michigan before earning his MD from the University of Illinois at Chicago in 1994. He also conducted PhD-level research in neuropharmacology at the University of Illinois at Chicago, giving him a strong scientific foundation in how the body and brain interact. He completed both his internship and residency in internal medicine at the University of Michigan Medical Center in Ann Arbor. The American Board of Internal Medicine certifies him in internal medicine.
Dr. O'Connor has practiced medicine in Chicago for decades, building long-term relationships with patients some of whom have been with him since the beginning of his career. His clinical interests include cognitive health, cardiac prevention, metabolic medicine, osteoporosis, nutrition, exercise medicine, and sleep. He views the physician-patient relationship as a privilege, and credits his patients with making him a stronger physician over time.
Education & Training
Undergraduate
BS, Biology, Hope College, Holland, MI, 1986
Medical School
MD, University of Illinois at Chicago, Chicago, IL, 1994
Residency
Internship and Residency, Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI
Additional Training
PhD Research, Neuropharmacology, University of Illinois at Chicago, Chicago, IL, 1990
Certifications
Conditions Treated
Who is Dr. O'Connor right for?
Dr. O'Connor is a strong fit for adults seeking a long-term relationship with a deeply experienced internist. Patients managing chronic conditions like metabolic disease, osteoporosis, or cardiovascular risk benefit from his broad clinical focus. His interest in cognitive health makes him a good match for patients thinking proactively about brain and aging concerns. Adults who want direct physician access, including after-hours cell phone contact, will find his practice well suited to their needs.
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Frequently Asked Questions
Dr. O'Connor treats a wide range of adult medical conditions. His clinical interests include metabolic disease, cardiovascular risk, cognitive health, osteoporosis, and sleep disorders. He also focuses on nutrition and exercise medicine as tools for disease prevention and health maintenance.
Yes, the American Board of Internal Medicine certifies Dr. O'Connor in internal medicine. He earned his MD from the University of Illinois at Chicago in 1994 and completed his residency at the University of Michigan Medical Center in Ann Arbor.
Dr. O'Connor conducted PhD-level research in neuropharmacology at the University of Illinois at Chicago. That training gave him a strong scientific foundation in how the body and brain interact. This background directly informs his interest in cognitive health and metabolic medicine.
Dr. O'Connor has practiced internal medicine in Chicago for decades. Many of his patients have been with him since the beginning of his career. He considers those long-term relationships central to his growth as a physician.
Dr. O'Connor takes a proactive approach to health. He focuses on cardiac prevention, metabolic health, cognitive function, nutrition, exercise, and sleep as core pillars of long-term wellness. His annual Comprehensive Wellness Evaluations give each patient a thorough, 60-minute review of their overall health.
Yes, members reach Dr. O'Connor directly by cell phone after hours and on weekends for urgent concerns. This direct access is one of the core benefits of membership in his practice.
Yes, Dr. O'Connor sees members for same-day or within-24-hour appointments when acute needs arise. This level of access ensures patients do not have to wait days or visit urgent care for time-sensitive concerns.
Dr. O'Connor specializes in internal medicine and preventive medicine. His clinical interests span cardiac prevention, cognitive health, metabolic medicine, osteoporosis, nutrition, exercise medicine, and sleep.
Doctor profile last updated March 21, 2026