About
Dr. Sean Cassleman grew up in Grosse Pointe, Michigan and earned his undergraduate degree at John Carroll University, where he played collegiate football. That early foundation in athletics shaped a lifelong commitment to physical fitness and performance. He went on to earn his medical degree from Michigan State University of Osteopathic Medicine. His residency training in Internal Medicine took place at Sinai Grace Hospital within the Detroit Medical Center, one of the busiest and most demanding clinical environments in the region.
Dr. Cassleman holds board certification in Internal Medicine and earned a Diplomate designation from the American Board of Obesity Medicine. He brings more than ten years of clinical experience treating patients in Saint Clair Shores and Detroit. His clinical passions include longevity medicine, metabolic health, hormone therapy for both men and women, weight management, osteoporosis, peptide therapy, advanced cardiovascular risk assessment, and cancer screening. He approaches care through a data-driven, prevention-first lens aligned with the work of longevity medicine pioneer Peter Attia. Dr. Cassleman holds licenses in Michigan, Florida, Tennessee, and Texas. He remains personally active in sports and fitness, a commitment that directly informs how he guides his patients.
Education & Training
Undergraduate
John Carroll University
Medical School
Michigan State University of Osteopathic Medicine
Residency
Internal Medicine, Sinai Grace Hospital, Detroit Medical Center
Additional Training
Diplomat of the American Board of Obesity Medicine
Certifications
Conditions Treated
Who is Dr. Cassleman right for?
Dr. Cassleman is a strong fit for adults who want proactive, data-driven care focused on long-term health and metabolic performance. Busy professionals and executives seeking thorough cardiovascular risk assessment, hormone optimization, or advanced cancer screening benefit from his clinical depth. He works well with patients managing obesity, insulin resistance, osteoporosis, or hormone-related concerns. Patients who value direct physician access and a team that integrates fitness, nutrition, and medicine will find his approach well-matched to their goals.
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Frequently Asked Questions
Dr. Cassleman focuses on metabolic disease, obesity, insulin resistance, diabetes, cardiovascular disease, dyslipidemia, hypertension, low testosterone, menopause, osteoporosis, sarcopenia, sleep apnea, fatty liver disease, and neurodegenerative disease risk. He also provides advanced cancer screening and chronic kidney disease management. His clinical scope reflects a career built around preventing and reversing the most common drivers of chronic illness.
Yes. Dr. Cassleman holds board certification in Internal Medicine and earned a Diplomate designation from the American Board of Obesity Medicine. He completed his medical degree at Michigan State University of Osteopathic Medicine and his Internal Medicine residency at Sinai Grace Hospital within the Detroit Medical Center.
Dr. Cassleman takes an early, prevention-focused, data-driven approach aligned with current longevity science. He prioritizes advanced diagnostics, metabolic optimization, strength and fitness, sleep, nutrition, and hormone health. Rather than waiting for disease to appear, he identifies and addresses risk factors years before they typically cause symptoms.
Yes. Dr. Cassleman provides testosterone replacement therapy for men and menopausal hormone therapy for women. He evaluates each patient individually using advanced lab testing and clinical assessment before recommending any hormonal intervention.
Dr. Cassleman orders advanced lipid panels including ApoB, NMR lipid profiles, Lp(a), fasting insulin, HOMA-IR, hs-CRP, and uric acid. He also coordinates whole body MRI, liquid biopsy, coronary calcium scoring, DXA bone density scanning, continuous glucose monitoring, genetic testing, and body composition analysis through InBody scanning.
Yes. Dr. Cassleman holds medical licenses in Michigan, Florida, Tennessee, and Texas. He offers virtual care to patients in those states and accepts requests for additional states on a case-by-case basis.
Dr. Cassleman played football at John Carroll University and has remained physically active throughout his career. That personal experience with training and performance directly shapes how he counsels patients on strength, fitness, and metabolic health. He integrates on-site gym training into his clinical model because he believes exercise is a core medical intervention, not an add-on.
Yes. Members receive Dr. Cassleman's cell phone number and email address and have 24/7 direct access to him. This level of access is a core part of how he practices and ensures patients never navigate an after-hours answering service for meaningful health concerns.
Dr. Cassleman offers four structured weight management tracks. The Executive Turnaround runs 24 weeks with biweekly physician visits alternating with coaching sessions. The Complete Transformation runs 24 weeks with monthly physician visits and alternating coaches. He also offers a physician-led Momentum program and a coach-led Momentum program with physician oversight. GLP-1 medication management integrates into these programs when appropriate.
Doctor profile last updated June 11, 2026