About
Dr. Mark Calarco brings 32 years of medical experience to his work in anti-aging, regenerative, and family medicine. His practice in Franklin, Tennessee serves a global clientele that includes professional athletes, entertainers, and senior business leaders seeking peak physical and cognitive performance.
Beyond clinical practice, Dr. Calarco co-founded American Addiction Centers in 2014 and helped guide the company through its initial public offering on the New York Stock Exchange. He served on its executive management team through 2022 and led its laboratory division as CEO from 2019 to 2022. During that time, he pioneered approaches in pharmacogenomics and comprehensive diagnostics that helped thousands of people with addiction. Tennessee Governor Bill Haslam appointed him to the State Medical Laboratory Board in 2014, and Governor Bill Lee reappointed him for a second term concluding in 2021. Dr. Calarco speaks Spanish, German, French, and Japanese fluently and is currently learning Danish. He lives in Brentwood, Tennessee with his wife and son. Outside medicine, he plays tennis and practices Historical European Martial Arts.
Languages
English, Spanish, German, French, Japanese, Danish
Conditions Treated
Who is Dr. Calarco right for?
Dr. Calarco is a strong fit for high-performing adults who want a highly personalized, science-driven approach to longevity. Professional athletes, executives, and entertainers seeking peak physical and cognitive performance make up much of his clientele. Patients interested in hormone optimization, cardiovascular prevention, or cancer prevention benefit from his comprehensive diagnostic approach. He works best with clients who come through referral and want a long-term partnership focused on biological age and healthspan.
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Frequently Asked Questions
Dr. Calarco specializes in anti-aging, regenerative, and functional medicine. His work focuses on optimizing physical and cognitive performance, extending healthy lifespan, and reducing biological age. He builds each program around the client's unique genetic and environmental history.
Dr. Calarco serves a global clientele that includes professional athletes, senior business executives, and world-renowned entertainers. All of his clients are adults seeking peak performance and long-term health optimization. EMP Health accepts new clients by referral only.
Dr. Calarco brings 32 years of medical experience to his practice. His background spans family medicine, functional medicine, preventive medicine, and executive health. He also has deep expertise in pharmacogenomics and comprehensive diagnostics developed through his leadership at American Addiction Centers.
Dr. Calarco speaks Spanish, German, French, and Japanese fluently. He is currently learning Danish. His multilingual ability supports his global clientele.
Dr. Calarco co-founded American Addiction Centers in 2014 and helped lead the company through its NYSE initial public offering. He served on its executive management team through 2022 and led its laboratory division as CEO from 2019 to 2022. Tennessee Governors Bill Haslam and Bill Lee both appointed him to the State Medical Laboratory Board.
Dr. Calarco offers hormone optimization, body composition optimization, cardiovascular prevention, cancer prevention, brain health, epigenomic modulation, pharmacogenomics, glycation inhibition, and comprehensive diagnostics. He tailors every program to the client's genetic and environmental history. His goal is to optimize both physical and cognitive function over the long term.
Dr. Calarco accepts a limited number of new clients each year. New clients must come through referral from a current client or colleague. This selective process allows him to maintain a high standard of individualized care.
Dr. Calarco starts every program with a thorough review of the client's genetic and environmental history. He builds personalized plans around three goals: optimizing physical and cognitive function, widening the gap between chronological and biological age, and extending healthy lifespan. No two plans look the same.
Doctor profile last updated March 21, 2026