About
Lee J. Guo, DO grew up in Boston and earned his Bachelor of Science in Biology from Boston College in 2005. He then relocated to Philadelphia to attend the Philadelphia College of Osteopathic Medicine, earning his Doctorate of Osteopathic Medicine in 2010. After graduation, he returned to Boston for a clinical research fellowship at Harvard Medical School Boston Children's Hospital in the Otolaryngology Department. During that fellowship, he co-authored the book chapter "Disorders of the Eustachian Tube" and contributed to original research on minimally invasive cholesteatoma surgery. He completed his internship and residency in Internal Medicine at Mercy Suburban Hospital in East Norriton, Pennsylvania, finishing in 2014. He holds certification as a Diplomate of the American Osteopathic Board of Internal Medicine.
Dr. Guo is the first Asian American MDVIP-affiliated physician serving the Main Line suburbs of Philadelphia. He speaks English, Mandarin Chinese, and Cantonese Chinese. His clinical passions include preventive medicine and community health. He belongs to the American Osteopathic Association, the American Medical Association, the Pennsylvania Osteopathic Medical Association, and the Pennsylvania Medical Society. Main Line Today Magazine named him a Top Doctor in 2024. Outside of medicine, Dr. Guo devotes time to his family, plays classical piano, collects coins, and explores the outdoors.
Education & Training
Undergraduate
Boston College, Bachelor of Science in Biology, 2005
Medical School
Philadelphia College of Osteopathic Medicine, Doctorate of Osteopathic Medicine, 2010
Residency
Residency in Internal Medicine, Mercy Suburban Hospital, East Norriton, PA, 2012-2014
Fellowship
Clinical Research Fellowship, Harvard Medical School Boston Children's Hospital, Otolaryngology Department, 2010-2011
Additional Training
Internship, Mercy Suburban Hospital, East Norriton, PA, 2011-2012
Certifications
Languages
English, Mandarin Chinese, Cantonese Chinese
Conditions Treated
Who is Dr. Guo right for?
Dr. Guo is a strong fit for adults across Delaware, Montgomery, and Chester Counties who want proactive, relationship-driven primary care. Patients managing chronic conditions or seeking thorough preventive screenings benefit from his osteopathic and internal medicine training. Mandarin- or Cantonese-speaking patients will find a physician who communicates fluently in their language. Adults who value same-day access and direct physician contact outside of office hours are well-suited to his practice.
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Frequently Asked Questions
Dr. Guo specializes in internal medicine and preventive medicine. He focuses on comprehensive wellness planning, chronic disease management, and health screenings. His osteopathic training informs a whole-person approach to adult care.
Yes. Dr. Guo holds certification as a Diplomate of the American Osteopathic Board of Internal Medicine. He earned his Doctorate of Osteopathic Medicine from the Philadelphia College of Osteopathic Medicine in 2010.
Dr. Guo completed his internship and residency in Internal Medicine at Mercy Suburban Hospital in East Norriton, Pennsylvania. He finished his residency training in 2014.
Yes. Dr. Guo speaks English, Mandarin Chinese, and Cantonese Chinese fluently. This makes him especially accessible to Mandarin- and Cantonese-speaking patients across the Main Line area.
Dr. Guo completed a clinical research fellowship at Harvard Medical School Boston Children's Hospital in the Otolaryngology Department. He co-authored the book chapter "Disorders of the Eustachian Tube" and contributed to original research on minimally invasive cholesteatoma surgery.
Dr. Guo sees adult patients across Delaware County, Montgomery County, and Chester County. His practice focuses on internal medicine and preventive care for the Main Line suburbs of Philadelphia.
Yes. Main Line Today Magazine named Dr. Guo a Top Doctor in 2024. He also holds membership in the American Osteopathic Association, the American Medical Association, the Pennsylvania Osteopathic Medical Association, and the Pennsylvania Medical Society.
Yes. Dr. Guo holds hospital privileges at Paoli Hospital in Paoli, Pennsylvania.
Doctor profile last updated March 21, 2026