About
Dr. Jay Moore founded Nexus Primary Care in Brentwood, Missouri in 2024. He earned his MD at the University of Missouri School of Medicine and completed a combined double residency in Internal Medicine and Pediatrics there as well, finishing in 2004. He holds board certification in Internal Medicine from the American Board of Internal Medicine.
Over 25 years, Dr. Moore built a career that spans clinical practice, hospital leadership, and national health policy work. He spent six years as a community-based primary care physician at SSM Wentzville before moving into administrative roles as VPMA at SSM DePaul. He then served as Chief Medical Officer at Anthem BCBS Missouri for seven years, advising employer groups ranging from two to two million people on benefit design. After roles as Medical Director at Paytient and Walmart Health, he launched Nexus. His clinical passions include aggressive cholesterol management, blood pressure control, ADHD diagnosis, GLP-1 weight loss treatment, gender-affirming care, sleep disorders, and evidence-based mindfulness. Outside medicine, Dr. Moore organizes Geekway to the West, a board game convention in St. Louis. He lives there with his wife, his dog, and what he describes as a too-large collection of science fiction books.
Education & Training
Medical School
University of Missouri School of Medicine (1996-2000)
Residency
Internal Medicine and Pediatrics (combined/double residency), University of Missouri (2000-2004)
Certifications
Conditions Treated
Who is Dr. Moore right for?
Dr. Moore is a strong fit for adults and teens ages 13 and up who want a primary care physician they can actually reach. Patients managing chronic conditions like hypertension, diabetes, high cholesterol, or ADHD benefit from his clinical depth and aggressive evidence-based targets. He works well with patients seeking gender-affirming care and those in the LGBTQIA+ community. College students, working adults with busy schedules, and anyone tired of waiting weeks for an appointment will find his model especially practical.
Similar Doctors Nearby
Dr. Barbara JostMD
diabetes, heart disease, high blood pressure +11 more
Dr. Robert SaltmanMD
diabetes, endocrine disorders, heart disease +9 more
Dr. Katherine Huhn-UsryMD
high blood pressure, high cholesterol, sinus infections +2 more
Frequently Asked Questions
Dr. Moore treats a broad range of conditions, including hypertension, diabetes, asthma, high cholesterol, seasonal allergies, depression, anxiety, ADHD, obesity, thyroid disorders, sleep disorders, and obstructive sleep apnea. He also handles acute needs like UTIs, strep throat, minor injuries, and coughs and colds. His scope includes gender-affirming care and GLP-1 weight loss medication management.
Yes. Dr. Moore holds board certification in Internal Medicine from the American Board of Internal Medicine. His ABIM verification ID is 230585. He completed both his MD and a combined Internal Medicine and Pediatrics residency at the University of Missouri.
Dr. Moore takes an aggressive, evidence-based approach to lipid management. He targets an LDL of 80 or lower for all his patients. He pairs that with close blood pressure monitoring and uses comprehensive biomarker tracking to guide treatment.
Yes. Dr. Moore provides gender-affirming care, including letters, referrals, and prescriptions. He has worked with the LGBTQIA+ community for more than ten years through volunteer work, professional organizations, and community outreach. Nexus is a fully affirming practice.
Dr. Moore treats depression and anxiety directly and integrates evidence-based mindfulness and meditation into many of his treatment plans. He recommends meditation for a wide range of conditions, from high blood pressure to emotional health concerns. He takes mental and emotional wellbeing seriously as part of whole-person primary care.
Dr. Moore spent 25 years in clinical medicine, hospital administration, and the health insurance industry. His roles included VPMA at SSM DePaul, CMO at Anthem BCBS Missouri, and Medical Director at both Paytient and Walmart Health. That experience gave him deep insight into how the system works and what patients actually need from a primary care physician.
Yes. Dr. Moore manages GLP-1 weight loss medications for his patients. He has access to a high-quality compounding pharmacy in St. Louis that offers these medications at less than half the standard cost. He takes a nuanced, patient-centered approach to weight and does not make weight loss the focus of every conversation.
Yes. Every Nexus member receives Dr. Moore's personal cell phone number. m. m. daily, including weekends. He responds as soon as he is able, and patients never navigate a phone tree or leave messages with an assistant.
Doctor profile last updated April 5, 2026