About
Dr. James Frost brings more than 25 years of medical experience to Signature Health & Wellness in Hardeeville, SC. A Baltimore native, he earned his undergraduate degree from The Johns Hopkins University before completing his Doctor of Medicine at UNC-Chapel Hill. He then trained in Family Medicine through a residency at the University of Virginia.
S. Air Force, reaching the rank of Major. He earned decorations for his service in Operations Iraqi and Enduring Freedom. He arrived in the Lowcountry in 2004 and founded Signature Health & Wellness in 2005. He holds admitting privileges at Coastal Carolina and Hilton Head Hospital, and previously held privileges at St. Joseph/Candler Hospitals in Savannah and Beaufort Memorial Hospital. He serves as Medical Director for Agape Hospice and maintains staff positions at several area nursing homes, including Sprenger and NHC in the Bluffton area. His clinical background spans office medicine, hospital medicine, emergency medicine, rehabilitation medicine, nursing home medicine, aerospace medicine, public health, and hospice/palliative care. Away from the practice, Dr. Frost lives in Jasper County with his wife, daughter, and four dogs. He gardens, farms, and dabbles in computers on his days off.
Education & Training
Undergraduate
The Johns Hopkins University, B.A. (Bachelor's Degree)
Medical School
UNC-Chapel Hill (Doctor of Medicine)
Residency
Family Medicine, University of Virginia
Additional Training
U.S. Air Force service; Aerospace Medicine experience
Conditions Treated
Who is Dr. Frost right for?
Dr. Frost suits adults seeking a primary care physician who stays closely involved across all stages of care. Patients managing chronic conditions like hypertension, diabetes, or elevated cholesterol benefit from his thorough, unhurried approach. He also serves patients who need hospital or specialist coordination and want their doctor advocating throughout. Snowbirds and part-time Lowcountry residents fit naturally into his practice, since he remains reachable year-round from anywhere.
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Frequently Asked Questions
Dr. Frost treats hypertension, diabetes, elevated cholesterol, and a broad range of chronic and acute illnesses and injuries. His background also covers hospital medicine, rehabilitation medicine, nursing home medicine, emergency medicine, and hospice/palliative care, giving him a wider clinical range than most family medicine physicians.
Yes. Dr. Frost gives members his cellphone and pager numbers, as well as his personal email for non-urgent matters. He remains reachable by phone, text, or email 24 hours a day, 365 days a year, including during his one annual vacation week.
Dr. Frost earned his undergraduate degree at The Johns Hopkins University and his medical degree at UNC-Chapel Hill. He completed his residency in Family Medicine at the University of Virginia. S. Air Force, where he gained experience in aerospace medicine and earned decorations for service in Operations Iraqi and Enduring Freedom.
Yes. Dr. Frost holds admitting privileges at Coastal Carolina Medical Center and Hilton Head Hospital. He previously held privileges at St. Joseph/Candler Hospitals in Savannah and Beaufort Memorial Hospital. He closely follows any patient he refers to a hospital or emergency room.
Absolutely. Dr. Frost has spent more than 20 years building professional relationships with specialists throughout the Lowcountry. When a member needs a referral, he handles the coordination personally. His connections often allow patients to get specialist appointments faster than they could on their own.
Dr. Frost moved to the Lowcountry in 2004 and has practiced in the area for over 20 years. He founded Signature Health & Wellness in 2005, making it the first concierge practice of its kind in the region.
Yes. Dr. Frost maintains staff positions at several area nursing homes, including Sprenger and NHC in the Bluffton area. He also holds admitting privileges at Coastal Carolina and Hilton Head Hospital and follows his patients closely when they require inpatient care.
Dr. Frost serves as Medical Director for Agape Hospice. His background in hospice and palliative care gives him experience guiding patients and families through serious illness with thoughtful, personalized support.
Doctor profile last updated April 4, 2026