About
Dr. Michael Knolle, DO is a board-certified Internal Medicine physician with over 20 years of clinical experience in Pennsylvania. He earned his undergraduate degree in General Science from Penn State University in 1986 and later completed a Master's degree in Nutrition Biochemistry at Penn State in 1993. He then graduated from Lake Erie College of Osteopathic Medicine. He holds active medical licenses in both Pennsylvania and Florida.
His hospital career began immediately after residency, when he worked simultaneously at all three Lancaster-area hospitals. He then spent nine years at Hanover Hospital before finishing his inpatient career at Lancaster General Hospital. During those years, he admitted patients from emergency departments for heart attacks, strokes, diabetic emergencies, and respiratory failure. In 2022, he founded Integrity Health Alliance to integrate conventional medicine with lifestyle and natural approaches. Outside the practice, Dr. Knolle runs competitively and has a deep passion for fitness. On his 60th birthday, he ran his fifth marathon on the historic course from Marathon to Athens, Greece, raising funds for Nea Zoi, an anti-human trafficking ministry. He and his wife Jennifer have two adult children, two dogs, two cats, and nine laying chickens.
Education & Training
Undergraduate
Penn State University, B.S. General Science, 1986 (transferred from University of Pittsburgh)
Medical School
Lake Erie College of Osteopathic Medicine
Additional Training
Penn State University, Master's degree in Nutrition Biochemistry, 1993
Certifications
Conditions Treated
Who is Dr. Knolle right for?
Dr. Knolle works well with adults managing chronic conditions like diabetes, hypertension, asthma, or cardiovascular disease. Patients who want a physician who addresses root causes and builds a personalized plan will find his approach a strong match. He serves individuals, families, and small business employees across a wide age range. Those who value faith-informed, whole-person care will feel at home in his practice. Members seeking access to on-site wellness tools like IV therapy, peptide therapy, and fitness facilities will also benefit from his comprehensive model.
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Frequently Asked Questions
Dr. Knolle focuses on internal medicine, preventive care, and lifestyle medicine. He has deep clinical experience managing diabetes, hypertension, asthma, obesity, and cardiovascular disease. His hospital background also gives him broad expertise in acute conditions including heart attack, stroke, and respiratory failure.
Yes. Dr. Knolle holds board certification in Internal Medicine. He earned his medical degree from Lake Erie College of Osteopathic Medicine and also holds a Master's degree in Nutrition Biochemistry from Penn State University.
Dr. Knolle uses both conventional pharmaceuticals and natural or lifestyle-based interventions. He treats each patient as a whole person, addressing mind, body, and spirit. He tailors care plans to root causes rather than managing symptoms in isolation. His practice reflects the six pillars of lifestyle medicine as a foundation for long-term health.
Dr. Knolle has practiced conventional medicine for over 20 years in Pennsylvania. He spent most of that career as a hospitalist at several hospitals across Lancaster County and at Hanover Hospital before founding Integrity Health Alliance in 2022.
Yes. Dr. Knolle integrates personalized nutrition into his care approach. His Master's degree in Nutrition Biochemistry from Penn State informs his clinical guidance on diet and metabolic health. The practice also offers nutritional health coaching through Kathy's Corner, staffed by an Integrative Nutrition Coach.
Yes. Dr. Knolle orders laboratory studies and radiologic imaging for members at significantly reduced cost. He also refers to specialists when appropriate, maintaining coordination of care as the primary physician.
Yes. Dr. Knolle offers a testosterone therapy program with multiple protocol options. He also offers peptide therapy for weight loss, including Semaglutide, Tirzepatide, and Retatutride. These services are available to both members and non-members on a fee-for-service basis.
Dr. Knolle founded Integrity Health Alliance as a Christ-centered practice. He built the practice on values of mutual love and respect, patient autonomy, and personal freedom. Faith in Jesus Christ is one of the core values he lists for the practice, and the team prays for members with intentional purpose.
Doctor profile last updated June 9, 2026