About
Matthew M. O'Brien, MD is a board-certified family physician with more than 20 years of practice in Wilmington, Delaware. He earned a Bachelor of Science in Applied Physics Engineering from Columbia University in 1986 before pursuing medicine. He completed his Doctorate of Medicine at Jefferson Medical College in Philadelphia in 1997. His internship and Family and Community Medicine residency both took place at Christiana Care Hospital System in Wilmington, where he trained from 1997 to 2000.
Medicine runs in Dr. O'Brien's family. He grew up in Wilmington, where both of his parents practiced as physicians, as do two of his siblings. He holds membership in the American Academy of Family Physicians and the Delaware Academy of Medicine. ChristianaCare appointed him as a clinical instructor for its Family Medicine Residency Program, and Jefferson Medical College holds a similar appointment. Since 2003, he has served as a preceptor for medical students and residents. He believes each patient deserves individual attention and approaches every visit with that philosophy in mind.
Education & Training
Undergraduate
Columbia University, School of Engineering and Applied Science, B.S. Applied Physics Engineering, 1986
Medical School
Jefferson Medical College, Philadelphia, PA — Doctorate of Medicine, 1997
Residency
Family and Community Medicine, Christiana Care Hospital System, Wilmington, DE, 1998-2000
Additional Training
Internship, Christiana Care Hospital System, Wilmington, DE, 1997-1998; Preceptor, Medical Students and Residents, 2003-present
Who is Dr. O'Brien right for?
Dr. O'Brien is a strong fit for adults seeking a primary care physician who knows them by name, not by chart number. Patients managing chronic conditions benefit from his thorough, unhurried approach to diagnostics and wellness planning. He serves patients across Wilmington and surrounding areas including Greenville, Hockessin, and Southern Chester County. Anyone who values direct after-hours phone access to their physician will find his practice a natural match.
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Frequently Asked Questions
Dr. O'Brien practices Family Medicine and holds board certification in that specialty. He has focused on individualized primary care for more than 20 years. His training took place entirely within Wilmington at Christiana Care Hospital System.
Yes, Dr. O'Brien holds board certification in Family Medicine. He earned his medical degree at Jefferson Medical College and completed his residency in Family and Community Medicine at Christiana Care Hospital System.
Dr. O'Brien earned his medical degree at Jefferson Medical College in Philadelphia in 1997. He completed both his internship and his Family and Community Medicine residency at Christiana Care Hospital System in Wilmington between 1997 and 2000.
Yes, personalized care is central to how Dr. O'Brien practices medicine. He treats each patient as an individual and builds wellness plans around the results of each person's annual MDVIP Wellness Program screenings. Visits run at a relaxed pace so patients have time to discuss their concerns fully.
Yes, Dr. O'Brien makes himself available by phone after hours, including on weekends. Patients can contact him for more urgent matters even while traveling. He answers calls personally rather than routing patients through an answering service.
Yes, Dr. O'Brien holds appointments as a clinical instructor for the ChristianaCare Family Medicine Residency Program and for Jefferson Medical College. He has also served as a preceptor for medical students and residents since 2003.
Dr. O'Brien maintains an affiliation with the ChristianaCare system in Wilmington, Delaware. He completed both his internship and residency there, and that relationship has continued throughout his career.
Dr. O'Brien is a member of the American Academy of Family Physicians and the Delaware Academy of Medicine. He also holds membership in the American Medical Association and the Medical Society of Delaware.
Dr. O'Brien sees patients from Wilmington, Delaware and surrounding communities. That includes Greenville, Hockessin, Centreville, Chadds Ford, and Southern Chester County.
Doctor profile last updated April 11, 2026