About
Dr. Mark Rosenbloom arrived at medicine after a career path few physicians share. He earned a BA Honours in Economics at McGill University, then completed his MBA at Stanford University. He went on to serve as Senior Executive Vice President of one of North America's largest publishing companies. That background in managing complex systems at scale informs how he approaches every patient relationship today. He earned his MD from Northwestern University Feinberg School of Medicine and completed his residency in Emergency Medicine at the University of Illinois College of Medicine. He later served as Associate Professor of Clinical Medicine and attending physician at Northwestern Memorial Hospital.
Years in high-acuity emergency care sharpened his pattern recognition and consequence-aware decision making. He observed repeatedly that acute disease often follows years of silent metabolic and vascular change. That insight drove him to build a structured longitudinal model integrating advanced biomarker analytics, hormonal optimization, metabolic monitoring, lipid particle evaluation, body composition analysis, aerobic capacity measurement, and cognitive assessment. He serves on the Medical Advisory Board of the Alzheimer's Treatment Centers of America and participates as a clinical investigator in emerging neurodegenerative therapies through FDA Expanded Access pathways. Both of his parents developed Alzheimer's disease, and his father underwent quadruple bypass surgery at 73. Those personal experiences fuel his clinical focus on cognitive preservation and cardiovascular resilience. At 73, he trains six days per week including MMA and Spartan racing, and his own VO2 max exceeds that of average men decades younger. He founded PEPID LLC, a medical software platform serving clinicians globally, and two public charities: the Unicorn Children's Foundation and the Boca School for Autism. He authored ALIVE AF: Outperform. Outlive. , available on Amazon.
Education & Training
Undergraduate
McGill University, BA Honours in Economics
Medical School
Northwestern University Feinberg School of Medicine
Residency
Emergency Medicine, University of Illinois College of Medicine
Additional Training
MBA, Stanford University
Conditions Treated
Who is Dr. Rosenbloom right for?
Dr. Rosenbloom is a strong fit for executives and high-performing adults who want continuous physician oversight, not annual checkups. Men and women navigating hormonal decline, metabolic drift, cardiovascular risk, or early cognitive concerns will find his model well-suited to their goals. Patients with a personal or family history of Alzheimer's disease benefit from his deep focus on neuroprotective strategy and longitudinal cognitive tracking. He works best with individuals willing to commit to measurement, protocol adherence, and structured reassessment over time.
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Frequently Asked Questions
Dr. Rosenbloom treats hormonal decline, testosterone deficiency, insulin resistance, metabolic dysfunction, cardiovascular disease risk, cognitive decline, Alzheimer's disease risk, obesity, visceral fat accumulation, muscle loss, sleep disorders, neuroinflammation, thyroid dysfunction, adrenal dysfunction, sexual dysfunction, and osteoporosis. His model addresses these as an integrated system rather than isolated findings.
Dr. Rosenbloom trained in Emergency Medicine at the University of Illinois College of Medicine and built his clinical foundation in high-acuity acute care. He earned his MD from Northwestern University Feinberg School of Medicine and later served as Associate Professor of Clinical Medicine at Northwestern Memorial Hospital.
Before pursuing medicine, Dr. Rosenbloom earned an MBA from Stanford University and served as Senior Executive Vice President of one of North America's largest publishing companies. He completed his undergraduate studies in Economics at McGill University. That background in systems management and executive decision-making directly shapes how he structures longitudinal patient care.
Dr. Rosenbloom tracks cognitive performance longitudinally using validated assessment tools including CNS Vital Signs. He monitors and manages eight primary drivers of cognitive decline: insulin resistance, neuroinflammation, cardiovascular deconditioning, muscle loss, sleep disruption, hormonal decline, omega-3 deficiency, and chronic cortisol elevation. Both of his parents developed Alzheimer's disease, and that personal history deepens his clinical focus on early cognitive preservation.
Yes. Dr. Rosenbloom serves both men and women. For women, he addresses the hormonal, metabolic, and structural changes associated with perimenopause and high-demand professional life, including estrogen and progesterone architecture, thyroid function, adrenal health, insulin dynamics, bone density, and cognitive trajectory.
Dr. Rosenbloom uses a precision diagnostic battery that includes ApoE genotype, MTHFR, pharmacogenomics, VO2 max testing, CNS Vital Signs cognitive baseline and longitudinal tracking, sleep architecture analysis, DEXA body composition and bone density, advanced lipid analytics, and over 100 metabolic markers. Every result connects to a specific clinical intervention.
Yes. Dr. Rosenbloom serves on the Medical Advisory Board of the Alzheimer's Treatment Centers of America. He also participates as a clinical investigator in emerging neurodegenerative therapies, including investigational agents available through FDA Expanded Access pathways.
Dr. Rosenbloom has received coverage in the Chicago Tribune, Voyage Chicago, Playboy Magazine, and WGN Channel 9 Chicago. He is also a keynote speaker on longevity and performance medicine and a member of an elite peer network for top-tier executives and entrepreneurs. He authored ALIVE AF: Outperform. Outlive. , available on Amazon.
Dr. Rosenbloom builds each protocol from comprehensive diagnostic data gathered at enrollment, then recalibrates it quarterly as biomarkers, body composition, and performance metrics evolve. He integrates hormonal, metabolic, cardiovascular, cognitive, and sleep variables as a unified system. One physician reviews and adjusts all variables, so no finding goes unconnected.
Doctor profile last updated August 19, 2026