About
Mark A. Isaeff, MD brings a foundation in molecular biology and a medical degree earned with distinction to his internal medicine practice in San Antonio. He studied Molecular Cell Biology at the University of California at Berkeley, graduating in 1992. He then earned his Doctorate of Medicine with Distinction from George Washington School of Medicine in 1998, taking home multiple awards including the Oscar Benwood Hunter Award and the Pathology Honor Society Award.
Dr. Isaeff completed both his internship and residency in Internal Medicine at the University of Texas Health Sciences Center at San Antonio. He served as Chief Resident in 2001-2002 and received awards for Excellence in Internal Medicine and Excellence in Outpatient Care. He holds board certification from the American Board of Internal Medicine. His clinical focus includes type 2 diabetes, high cholesterol, and hypertension. Patients and colleagues alike recognize his skill in analyzing complex diagnostic findings and communicating results clearly. Dr. Isaeff draws personal meaning from faith, family, and community, values that shape how he builds relationships with every patient he serves.
Education & Training
Undergraduate
University of California at Berkeley, Bachelor of Science, Molecular Cell Biology, 1992
Medical School
George Washington School of Medicine, Doctorate of Medicine with Distinction, 1998
Residency
Internal Medicine, University of Texas Health Sciences Center at San Antonio, 1999-2001; Chief Resident 2001-2002
Additional Training
Internship: Internal Medicine, University of Texas Health Sciences Center at San Antonio, 1998-1999
Certifications
Conditions Treated
Who is Dr. Isaeff right for?
Dr. Isaeff suits adults who want a long-term primary care relationship with direct physician access. Patients managing chronic conditions like type 2 diabetes, hypertension, or high cholesterol benefit from his attentive, thorough approach. He works well with patients who value detailed review of labs and diagnostics. Those who want same-day availability and after-hours phone access find his practice a natural fit.
Similar Doctors Nearby
Dr. Patrick PetersMD
type 2 diabetes, high cholesterol, hypertension +1 more
Dr. Erin ReeseM.D.
diabetes, chronic medical conditions, acute illnesses +2 more
Dr. Jose LopezMD
type 2 diabetes, high cholesterol, hypertension
Frequently Asked Questions
Dr. Isaeff focuses on internal medicine with particular depth in managing type 2 diabetes, high cholesterol, and hypertension. He also delivers comprehensive preventive screenings through the MDVIP Wellness Program. Patients credit him with identifying complex causes behind symptoms that other physicians missed.
Yes, Dr. Isaeff holds board certification from the American Board of Internal Medicine. He earned his medical degree with distinction from George Washington School of Medicine and completed his residency training at the University of Texas Health Sciences Center at San Antonio.
Dr. Isaeff completed his internship and residency in Internal Medicine at the University of Texas Health Sciences Center at San Antonio. He served as Chief Resident during 2001-2002 and received awards for Excellence in Internal Medicine and Excellence in Outpatient Care. Before medical school, he studied Molecular Cell Biology at the University of California at Berkeley.
Dr. Isaeff takes time to explain diagnoses and test results in clear, accessible language. Patients consistently note that he never rushes appointments and welcomes questions. His approach centers on understanding each patient as an individual and building a relationship grounded in trust.
Yes, Dr. Isaeff has a strong track record with diagnostically challenging cases. Patient reviews describe him identifying causes of complex symptoms that multiple other physicians could not resolve. His thorough analysis of bloodwork and lab results is a hallmark of his clinical style.
Yes. Dr. Isaeff makes himself available by phone after hours and on weekends. Members reach him directly, not a call service or on-call provider they have never met.
Yes. Every office visit is with Dr. Isaeff himself. The practice does not route patients to nurse practitioners or physician assistants.
Dr. Isaeff holds hospital privileges at Metropolitan Methodist in San Antonio. He can also help coordinate care with specialists at Medical Centers of Excellence for patients who need services beyond what is available locally.
Doctor profile last updated March 22, 2026