About
Dr. Jessica Knape founded HealthSpan Internal Medicine in Boulder, Colorado, bringing a clinical background that spans hospital medicine, assisted living, memory care, and home-based medical programs. S. D. with honors from the University of California, San Francisco in 2004. A. in Education from Stanford. Her Internal Medicine residency took place at the University of Colorado.
Dr. Knape holds dual board certification from the American Board of Internal Medicine and the American Board of Integrative and Holistic Medicine. 0 Certified Physician, an IntellxxDNA Certified Physician, and trained in Functional Medicine through the IMFCP. She also holds certification in Clinical Metabolomics with HOMe/HOPe. More than a decade of work with patients facing dementia and cognitive decline deepened her commitment to brain health, which led directly to the creation of the BrainSpan program. Dr. Knape is a 200-hour and 80-hour Advanced Yoga Teacher trained in Forrest Yoga, and she integrates yoga, mindfulness, and meditation into her clinical work. She lives in Boulder with her husband Carlos, their three children, and two dogs.
Education & Training
Undergraduate
Stanford University, B.S. Biology (1995–1999), with honors
Medical School
University of California, San Francisco (M.D., 2000–2004), with honors
Residency
Internal Medicine, University of Colorado (2006–2008)
Additional Training
M.A. in Education, Stanford University (1999)
Certifications
Conditions Treated
Who is Dr. Knape right for?
Dr. Knape is a strong fit for adults seeking a root-cause approach to chronic or complex health concerns. Patients navigating perimenopause, andropause, metabolic syndrome, or cognitive decline benefit directly from her areas of deepest expertise. She works well with adults who want advanced genomic or metabolic testing alongside thorough clinical guidance. Patients concerned about dementia prevention or early cognitive changes find particular value in her BrainSpan program. Her 60-minute appointments suit patients who want time to discuss their full health picture.
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Frequently Asked Questions
Dr. Knape treats a wide range of adult conditions with particular depth in cognitive decline, brain fog, dementia prevention, perimenopause, menopause, andropause, metabolic syndrome, insulin resistance, type 2 diabetes, thyroid and adrenal dysfunction, chronic fatigue, and cardiovascular risk. She also manages autoimmune conditions, fibromyalgia, osteopenia, anxiety, sleep disorders, post-COVID fatigue, mold toxicity, and gut health imbalance.
Yes. Dr. Knape holds dual board certification from the American Board of Internal Medicine and the American Board of Integrative and Holistic Medicine. She has maintained both certifications since 2010 and 2014, respectively.
Dr. Knape graduated with honors from the University of California, San Francisco School of Medicine in 2004 and completed her Internal Medicine residency at the University of Colorado. S. A. in Education from Stanford University. She brings over 20 years of clinical experience across hospital, clinic, assisted living, memory care, and home-based settings.
The BrainSpan program is Dr. Knape's physician-supervised approach to brain health and cognitive optimization. 0 model after spending over a decade caring for patients in memory care and assisted living settings. 0 Certified Physician and create a structured program focused on prevention and restoration of brain function.
Dr. Knape conducts detailed patient interviews that go well beyond a standard visit. She evaluates genetics, lifestyle, diet, stress levels, environmental exposures, and advanced biomarkers including genomics and metabolomics. She then builds personalized treatment plans targeting root causes rather than symptoms alone.
Yes. Dr. Knape is a 200-hour and 80-hour Advanced Yoga Teacher trained in Forrest Yoga. She holds certification in Clinical Mindfulness and Meditation and incorporates these practices into her clinical recommendations alongside conventional and functional medicine tools.
Dr. Knape uses IntellxxDNA genomic testing, for which she holds certification as an IntellxxDNA Certified Physician. She offers several Clinical Genomics packages, including Cognition, Neurodevelopment, Executive, and Powerhouse tiers. These packages help guide precision treatment decisions based on each patient's genetic profile.
Yes. Dr. Knape treats adults of all genders. She offers dedicated men's health care including andropause evaluation, testosterone optimization, metabolic health, cardiovascular risk assessment, and brain health. Her hormone and longevity programs address both male and female physiology.
0 protocol, a comprehensive, multi-factor approach to reversing cognitive decline. She identifies and addresses contributors such as insulin resistance, hormonal imbalance, inflammation, sleep disruption, nutrient deficiencies, and toxic exposures. She works collaboratively with clinical neuropsychologist Dr. Ilene Naomi Rusk and pharmacist Dr. Neda Leonard at Precision Medical Center.
Doctor profile last updated April 27, 2026
