About
Dr. Jeffrey Gladden graduated with Honors in Medicine from Temple University School of Medicine and built a distinguished career spanning interventional, diagnostic, preventive, and programmatic cardiology. He co-founded The Heart Hospital Baylor Plano in 2004 and serves there as Director of Heart Attack and Stroke Prevention and Cardiac Rehabilitation. He holds board certification as an interventional cardiologist and earned the FACC designation. His research appears in multiple peer-reviewed medical journals, and he consults on cardiovascular programs and medical device development.
In his mid-fifties, Dr. Gladden faced fatigue, anxiety, and depression. He refused the standard explanation and instead pursued the question that now drives his practice: how good can I be? That pivot led him to found Gladden Longevity and dedicate his clinical work to longevity medicine, biological age reversal, epigenetic testing, peptide therapy, NAD therapy, and mitochondrial function. He currently leads the LIFE-RAFT trial investigating age reversal. He authored the book '100 is the New 30' and hosts the Gladden Longevity Podcast. Outside medicine, Dr. Gladden surfs, mountain bikes, snowboards, runs, hikes, and plays guitar.
Education & Training
Medical School
Temple University (Honors in Medicine)
Certifications
Conditions Treated
Who is Dr. Gladden right for?
Dr. Gladden is a strong fit for adults who want to address aging at a biological level. Patients with cardiovascular risk, metabolic dysfunction, fatigue, or hormonal imbalance benefit from his deep clinical background. Executives and high performers seeking comprehensive annual assessments and data-driven optimization find his approach well-matched. He also works with patients who have not found answers through conventional medicine and want a more proactive framework.
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Frequently Asked Questions
Dr. Gladden treats cardiovascular disease, hypertension, metabolic dysfunction, fatigue, anxiety, depression, and arterial disease. He also works with patients seeking to lower their biological age and optimize long-term healthspan. His background as a board-certified interventional cardiologist informs his approach to heart attack and stroke prevention.
Yes. Dr. Gladden holds board certification as an interventional cardiologist and carries the FACC designation from the American College of Cardiology. He trained at Temple University School of Medicine, where he graduated with Honors in Medicine.
Dr. Gladden focuses on longevity medicine, biological age reversal, hormone optimization, epigenetic age testing, and cardiovascular disease prevention. He integrates peptide therapy, NAD therapy, and regenerative protocols into personalized programs. His clinical interests also include mitochondrial function and the hallmarks of aging.
The LIFE-RAFT trial stands for Life Energy Resilience and Antifragility Trial. Dr. Gladden designed the trial to investigate whether the aging process can be clinically reversed. It represents one of the more forward-looking research efforts at Gladden Longevity.
Yes. ' The book outlines his framework for personalized longevity strategy and reflects the core philosophy behind Gladden Longevity.
Yes. ' New episodes release every Thursday at noon.
Dr. Gladden spent his career as an interventional cardiologist before transitioning to longevity medicine. He co-founded The Heart Hospital Baylor Plano in 2004 and continues to serve as Director of Heart Attack and Stroke Prevention and Cardiac Rehabilitation there. He also serves as CEO, CMO, and board member at Scientia Cardio Access and Scientia Vascular.
Dr. Gladden typically works with adults who want to optimize their performance, extend their healthspan, and actively manage the biological drivers of aging. Many patients come with cardiovascular concerns, metabolic issues, or unexplained fatigue. High performers and executives make up a significant portion of his patient population.
Doctor profile last updated April 11, 2026