About
Bruce Yaffe, MD is a board-certified internist and board-certified gastroenterologist based in New York City. He trained at Mount Sinai Hospital and has practiced medicine for 30 years. Castle Connolly has listed him as a Top Doctor in New York Magazine for approximately 15 years. He holds hospital affiliations at NYU and Lenox Hill.
Dr. Yaffe serves as a spokesperson for the American Cancer Society on colon cancer prevention. He has averaged 20 to 30 colonoscopies and endoscopies per week across his career and performed Al Roker's on-air colonoscopy to promote screening awareness. His clinical passions span preventive cardiology, cancer prevention, neurocognitive decline, genetic testing, liquid biopsies, nutrition, and integrative medicine. He uses tools like the Grail Galleri blood test, coronary artery calcification scoring, and Cambridge Brain Sciences neurocognitive assessments. Dr. Yaffe approaches each patient relationship as a collaboration, working through problems together rather than in isolation. He welcomes a brief introductory phone call with prospective patients and notes that a sense of humor is always appreciated.
Education & Training
Residency
Mount Sinai Hospital, New York
Certifications
Conditions Treated
Who is Dr. Yaffe right for?
Dr. Yaffe is a strong fit for adults who want a proactive, prevention-focused physician with broad clinical expertise. Patients concerned about cancer risk, heart health, or cognitive decline benefit from his advanced screening tools. He works well with busy professionals and families spread across multiple cities or countries. His telehealth access makes him practical for patients who travel frequently or live outside New York. Those who appreciate a collaborative, direct doctor with a sense of humor tend to thrive in his practice.
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Frequently Asked Questions
Dr. Yaffe treats a wide range of conditions across internal medicine and gastroenterology. His clinical focus includes cancer prevention, preventive cardiology, neurocognitive decline, sleep disorders, anxiety and depression, and gastrointestinal conditions. He also addresses nutrition, genetic risk factors, and cognitive health using advanced diagnostic tools.
Yes, Dr. Yaffe holds dual board certifications in internal medicine and gastroenterology. He trained at Mount Sinai Hospital and has practiced medicine for 30 years. His certifications reflect his expertise across both primary care and specialty GI medicine.
Dr. Yaffe uses the Grail Galleri liquid biopsy to screen for multiple cancer types from a single blood draw. He also performs coronary artery calcification scoring for cardiac risk assessment and Cambridge Brain Sciences neurocognitive testing for cognitive health. He incorporates genetic testing into his preventive care approach as well.
Yes, Dr. Yaffe performs colonoscopies and endoscopies as part of his gastroenterology practice. He has averaged 20 to 30 procedures per week over his career. He also serves as a spokesperson for the American Cancer Society on colon cancer prevention and performed Al Roker's on-air colonoscopy to promote screening awareness.
Yes, Dr. Yaffe serves patients across the country and internationally. About 60% of his patients live outside New York City, with members in Florida, the Hamptons, London, Texas, and Los Angeles. He connects with remote patients through telehealth, phone, and text.
Dr. Yaffe treats each patient relationship as a collaboration. He works through problems alongside patients rather than delivering directives from a distance. He welcomes a brief introductory phone call for prospective patients who want to get a sense of his style before joining.
Dr. Yaffe holds hospital affiliations at NYU and Lenox Hill in New York City. These affiliations support his ability to coordinate care across specialist and hospital settings when his patients need them.
Castle Connolly has listed Dr. Yaffe as a Top Doctor in New York Magazine for approximately 15 years. He also serves as a spokesperson for the American Cancer Society, focusing on colon cancer prevention and public screening awareness.
Doctor profile last updated March 21, 2026