About
Anne Michele Safley, MD is a board-certified internist who trained at some of the most respected institutions in the country. She earned her Doctor of Medicine from Duke University School of Medicine in 2004. Her residency path took her through the University of Chicago, Mayo Clinic, and the University of Iowa Hospitals and Clinics. She later completed a Fellowship in Hospital Medicine at the University of Colorado Hospital in 2013.
Dr. Safley holds certification from the American Board of Internal Medicine and belongs to the Colorado Medical Society and Denver Medical Society. She is passionate about women's health, preventive care, and the collaborative management of complex chronic conditions. Her patients consistently describe her as kind, thorough, and communicative. A breast cancer survivor herself, Dr. Safley brings personal depth to her work with patients navigating serious illness. Outside the clinic, she enjoys hiking, skiing, swimming, music, and exploring Colorado with her two children.
Education & Training
Medical School
Duke University School of Medicine, Doctor of Medicine, 2004
Residency
The University of Chicago, 2004-2005; The Mayo Clinic, 2005-2006; University of Iowa Hospitals and Clinics, 2006-2009
Fellowship
Fellowship in Hospital Medicine, University of Colorado Hospital, 2013
Additional Training
NIH Postbaccalaureate Pre-Intramural Training Award, 9/1998-4/2000; Association of Pathology Chairs Honor Society, 4/2000
Certifications
Conditions Treated
Who is Dr. Safley right for?
Dr. Safley works well with adults who want a long-term relationship with a thorough, attentive physician. Women navigating perimenopause, hormone changes, or bone health concerns benefit from her focused expertise. Patients managing chronic conditions such as hypertension, diabetes, heart failure, or high cholesterol find her approach to be methodical and individualized. Adults seeking proactive cancer screening, cardiovascular monitoring, or medical weight loss with GLP-1 therapies are also a strong match. Her geriatric medicine focus makes her a good fit for older adults prioritizing healthy aging and stroke prevention.
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Frequently Asked Questions
Dr. Safley treats a wide range of adult medical conditions. These include hypertension, heart failure, diabetes, high cholesterol, obesity, osteoporosis, depression, anxiety, and fatigue. She also manages perimenopause and provides comprehensive cancer screening and chronic disease care.
Yes. Dr. Safley holds board certification in internal medicine from the American Board of Internal Medicine, earned in 2018. She trained at Duke University School of Medicine and completed residency training at the University of Chicago, Mayo Clinic, and the University of Iowa Hospitals and Clinics.
Dr. Safley earned her MD from Duke University School of Medicine in 2004. She completed residency training across three institutions: the University of Chicago, Mayo Clinic, and the University of Iowa Hospitals and Clinics. She then completed a Fellowship in Hospital Medicine at the University of Colorado Hospital in 2013.
Yes. Women's health is one of Dr. Safley's core clinical interests. She provides care for perimenopause, hormone replacement therapy, bone health, and cervical and breast cancer screening. She takes a personalized approach tailored to each woman's health history and goals.
Dr. Safley believes that good medicine begins with genuine listening. She works to build respectful, trusting relationships with each patient and partners with them to pursue individual health goals. Her appointments run 30 to 60 minutes, giving patients real time to discuss concerns thoroughly.
Yes. Dr. Safley offers medical weight loss support including GLP-1 therapies and dietary and nutraceutical counseling. She takes a comprehensive approach that considers each patient's metabolic health, lifestyle, and individual goals.
Yes. Dr. Safley has a dedicated focus on geriatric medicine. She helps older adult patients pursue healthy aging through individualized preventive care, cardiovascular monitoring, stroke prevention, and management of mental health concerns such as depression and anxiety.
Yes. Members at Cherry Hills Medicine have 24/7 phone access to Dr. Safley. This direct availability for urgent concerns is a core part of the practice's membership model.
Doctor profile last updated June 9, 2026