About
Anna Athena Manatis, MD, MPH, studied anthropology at Harvard University before earning her MD at New York University School of Medicine. She completed her residency in internal medicine at Albany Medical Center, where she also finished her internship in medicine and pediatrics. Years later, she returned to Harvard for a Master of Public Health in Occupational and Environmental Health. She holds board certification in internal medicine and is currently working toward Menopause Society Certified Practitioner (MSCP) certification. Her clinical focus spans perimenopause, menopause, hormone therapy, postpartum care, postpartum depression, women's cardiac risk, and genetic and environmental cancer risk. She has prescribed hormone therapy throughout her career, watching the field move from overprescribing to underprescribing to a more nuanced middle ground.
Dr. Manatis has lived on Cape Cod since 1989 and practiced medicine in East Sandwich for 20 years, at one point holding privileges at three hospitals simultaneously. She brings over 30 years of clinical experience to The Doctor's In. Her path to medicine began early, rooted in watching her mother practice medicine from their home in Greece. The Barnstable District Medical Society named her Community Clinician of the Year in 2019. She served twice as President of the Barnstable District Medical Society and sat on the Board of Trustees of the Massachusetts Medical Society. Outside the office, she babysits her grandchildren, cares for three Pointer Setters from the same litter, and spends time on the water swimming, kayaking, and reading.
Education & Training
Undergraduate
Harvard University, AB, Anthropology, 1974–1978
Medical School
New York University School of Medicine, MD, 1981–1985
Residency
Internal Medicine, Albany Medical Center, 1986–1988
Additional Training
Internship in Medicine & Pediatrics, Albany Medical Center, 1985–1986; Harvard School of Public Health, MPH, Occupational & Environmental Health, 2004–2007
Certifications
Conditions Treated
Who is Dr. Manatis right for?
Dr. Manatis is a strong fit for adults who want an internist with deep roots in women's health. Patients navigating perimenopause, menopause, or postpartum recovery benefit from her decades of focused clinical experience in those areas. She works well with women managing cardiac risk, hormone imbalance, or complex chronic conditions like hypertension, hyperlipidemia, or arrhythmia. Patients who value direct access to their physician, thorough visits, and same-day availability for urgent concerns will find her practice well matched to those needs. Her background in occupational and environmental health also makes her a good fit for patients with concerns about genetic or environmental cancer risk.
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Frequently Asked Questions
Dr. Manatis specializes in internal medicine with particular depth in women's midlife health. She treats perimenopause, menopause, postpartum depression, women's cardiac risk, hormone imbalance, and genetic and environmental cancer risk. She also manages hypertension, arrhythmia, hyperlipidemia, fatigue, and anxiety.
Yes. Dr. Manatis holds board certification in internal medicine. She is currently working toward certification as a Menopause Society Certified Practitioner (MSCP), adding formal credentials to decades of clinical practice in women's midlife health.
Dr. Manatis earned her MD at New York University School of Medicine and completed her residency in internal medicine at Albany Medical Center. She later earned a Master of Public Health in Occupational and Environmental Health from the Harvard School of Public Health.
Dr. Manatis has over 30 years of clinical experience. She practiced in East Sandwich for 20 years and spent time at Mass General and Mass General Brigham in Hingham before returning to Cape Cod to open The Doctor's In.
Dr. Manatis has prescribed hormone therapy throughout her career. She has followed the field through shifting guidance, from overprescribing to underprescribing to a more nuanced evidence-based approach. She treats each patient individually, considering their full health picture before making recommendations.
Dr. Manatis takes postpartum care well beyond the standard six-week visit. She stays reachable by text for new mothers managing physical recovery, fatigue, mood changes, or postpartum depression. She screens for and manages postpartum depression directly, recognizing that symptoms often surface long after the standard follow-up.
Dr. Manatis conducts women's cardiac risk assessments with a focus on how heart disease presents differently in women. She pays close attention to symptoms like unexplained fatigue, shortness of breath, and atypical pain patterns that can be missed. She understands how menopause affects cardiovascular risk and monitors those changes proactively.
Yes. Dr. Manatis assesses both genetic and environmental cancer risk as part of her clinical work. Her Master of Public Health in Occupational and Environmental Health from Harvard gives her a strong foundation for evaluating environmental exposures alongside genetic factors.
Yes. The Barnstable District Medical Society named her Community Clinician of the Year in 2019. She served twice as President of that organization and held a seat on the Board of Trustees of the Massachusetts Medical Society. She also received the Local Hero Award from the Cape and Islands Self Reliance Corporation in 2000.
Doctor profile last updated October 31, 2026